Adaptive Cardiac Pacing

CResPace is a H2020 consortium of 8 academic and industrial partners which develops adaptive bioelectronics to provide innovative therapy for chronic cardiorespiratory disease. The technology implements small neural networks known as central pattern generators that respond to physiological feedback in real time, are safer, simpler, non invasive and have autonomy exceeding the patient lifespan.  By providing novel therapies for arrhythmias, heart failure and their comorbidities such as sleep apnoea and hypertension, CResPace is working to extend patient’s life and quality of life.


The technology mimics the function of medullary neural circuits located at the base of the brain which regulate cardiac function by responding to changes in physiological feedback. These circuits, known as Central Pattern Generators (CPGs), are small neural networks which control respiration, the synchronization between heart and lungs,  the coordination between muscles responsible for swallowing… The loss of heart rate modulation by medullary CPGs is an early prognosis of heart failure.  Central pattern generators therefore provide an effective means of restoring heart rate variability and adaptation which can reverse the effects of chronic heart disease.

Neural pacemaker

VLSI pacemaker



University of BathPhysics
Dr Alain Nogaret,

University of Bristol, Physiology
Prof Julian Paton

University of Zurich, Neuromorphic Engineering
Prof Giacomo Indiveri

Mr Tracy Wotherspoon

Dr Berthold Steggemann

University of Vienna, Cardiology
Prof Mariann Gyongyosi

University of Utrecht, Physiology
Prof Marc Vos

International Clinical Research Centre, Brno
Dr Viola Galligioni

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